Clinical Coordinating Center (CCC)

Dr. Callaway studies resuscitation medicine with special emphasis on brain injury after cardiac arrest. He has developed a translational research program devoted to the topic of resuscitation from sudden death. Emphasizing the continuity of care during resuscitation, he has collaborated with prehospital care providers and emergency physicians to study acute cardiac interventions, developed a platform to study intensive care interventions, and worked with partners in rehabilitation to study long-term outcomes after cardiac arrest. Work in prehospital care has led to studies about acute monitoring and regionalization of care. Work with emergency providers has stimulated interest in provider safety and wellness, particularly related to shift-work and sleep deprivation. Basic laboratory investigations support and are informed by this clinical work.

Dr. Silbergleit has expertise in organizing and conducting clinical trials in the acute care setting. He has substantial past experience as a translational researcher, working on laboratory animal models of brain injury, and participating in clinical trials in stroke as a site PI and sub-investigator. For the past seven years, he has been a leading co-investigator in the formation and organization of the Neurological Emergencies Treatment Trials network, where he contributed to the oversight and management of all SIREN-NETT trials. In the SIREN-NETT he has developed specific expertise and experience in investigating initial interventions in patients with status epilepticus and neurotrauma. In multiple trials, he has developed operational and academic expertise in Exception from Informed Consent (EFIC) for Emergency Research and its conduct under FDA regulations. He is also PI of a just-funded NIH empirical ethics project to study the review of local context by local and central IRB's.