Trial Updates
11/20/25 — ICECAP Supplemental Data Request
ICECAP sites are asked to submit supplemental patient data to support upcoming analyses on illness severity, temperature control quality, and overdose-related OHCA outcomes. A new webpage is now available with …
9/24/25 – ICECAP Publication Memo from ICECAP Leadership
We are working to get all data monitored – and this is a large task. We anticipate this will be completed in early winter. Please share this memo with others …
The letter from the NIH Central IRB on closing enrollment to ICECAP has been posted on the ICECAP workbench under “Institutional Review Board”. Please reach out to trial leadership if …
Overview
Neurological death and disability are common outcomes in survivors of cardiac arrest. Therapeutic cooling of comatose patients resuscitated from shockable rhythms markedly increases the rate of good neurological outcome, but poor outcomes still occur in as many as 50%, and the benefit of cooling in those resuscitated from asystole and pulseless electrical activity has not been shown in a randomized study.
The Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) study will enroll comatose adult survivors of out of hospital cardiac arrest that have already been rapidly cooled using a definitive temperature control method. Those with and without initial shockable rhythms will be studied as distinct populations (maximum of 1800 subjects over four years). ICECAP will determine if identifying an optimal duration of cooling can improve outcomes, and if development of a duration response curve can substantiate efficacy in a wider patient population.
Contact
Emergency 24-Hour Study Hotline:
1-833-4-ICECAP (1-833-442-3227)
Outcomes Team:
Angi Caveney ([email protected]), Lead Neuropsychologist;
Joy Black ([email protected]), Central Outcomes Assessor;
Courtney Miller ([email protected]), iPad & iCloud support ;
& Sofia Perez ([email protected]), Co-trainer & QA Reviewer
Education (training, website access, material development, technical support):
Courtney Miller ([email protected])
WebDCU Support (user account requests, technical support, CRF completion):
Sara Butler ([email protected]) (843) 792-1599 & Sarah Wells ([email protected]) (843) 876-1129
Site Management and Other Inquiries:
Nia Bozeman ([email protected])
or [email protected]
Finances:
Valerie Stevenson ([email protected])