Trial Updates Overview Traumatic brain injury (TBI) is a major cause of death and disability in developed societies. Every year, approximately 3.5 million Americans sustain a TBI, of which 50,000 die, and another 300,000 are hospitalized and survive the injury. BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for … Read more
Study Updates Overview Many patients now survive out-of-hospital cardiac arrest (OHCA), however gaps in knowledge about long-term outcomes result in a fragmented and underdeveloped continuum of care to achieve recovery. Recovery is defined as significant improvement in functional and cognitive outcomes and health-related quality of life. OHCA Survivors with favorable recovery patterns may potentially go … Read more
Trial Updates Please join the SIREN CCC in welcoming our new KESETT Site Manager, Vincent Cervantes. Vincent will be the primary point of contact for KESETT site management questions. His contact is vcervant@med.umich.edu. Overview Generalized convulsive status epilepticus (long-lasting convulsive seizures) is a dangerous but common neurologic emergency; it can cause respiratory depression and permanent brain … Read more
Trial Updates Overview This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. The study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result … Read more
Trial Updates Overview Neurological death and disability are common outcomes in survivors of cardiac arrest. Therapeutic cooling of comatose patients resuscitated from shockable rhythms markedly increases the rate of good neurological outcome, but poor outcomes still occur in as many as 50%, and the benefit of cooling in those resuscitated from asystole and pulseless electrical … Read more
Trial Updates Overview There continues to be an overarching problem of high mortality and poor outcome for victims of severe traumatic brain injury (TBI). Preclinical and clinical investigations indicate that hyperbaric oxygen (HBO2) has a positive impact on reducing brain injury and improving outcomes in severe TBI. By markedly increasing oxygen (O2) delivery to the … Read more