Journal Club

About Journal Club

The SIREN Journal Club is a 1-hour discussion among research investigators, staff, and any others interested in the learning and discussion of research. All are welcome. Registration is not required. Journal Club is held on the 3rd Wednesday of the Month. Journal Club breaks for July, August, and December.

The objectives of this Journal Club are to:

  • Recognize and improve knowledge and skills of current practice and research;
  • Analyze the information presented; and
  • Identify implications for practice/research.

Physicians:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Michigan Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Dr. Jarron Mosier will be presenting “High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure. The RENOVATE Randomized Clinical Trial”. Dr. Jarrod Mosier is an Associate Professor of Emergency Medicine and Internal Medicine at the University of Arizona. He is an Associate Program Director for the Pulmonary Critical Care fellowship and the medical director for the ECMO service. Dr. Mosier also serves as the national course director for The Difficult Airway Course: Critical Care. His research interests include advanced airway management, acute respiratory failure, ECMO, and critical care delivery.

Dr. Joseph Finney will be presenting “Midazolam and Ketamine for Convulsive Status Epilepticus in the Out-of-Hospital Setting”. Joseph Finney, MD, is a Washington University pediatric emergency medicine and EMS physician.  He is board certified in pediatrics, pediatric emergency medicine, and emergency medical services (EMS). He serves as the director of EMS at St. Louis Children’s Hospital and Missouri EMS for Children Director of Prehospital Readiness. Dr. Finney is committed to simplifying the prehospital care of children through interactive education, research, and quality improvement. In addition to his clinical and educational activities, Dr. Finney focuses his time on prehospital research in pediatric seizure management and manual ventilation with particular interest in the use of ketamine for prehospital benzodiazepine refractory status epilepticus. 

Dr. William Meurer will be presenting: Taccone, F. S., Bittencourt, C. R., Møller, K., Lormans, P., Quintana-Díaz, M., Caricato, A., Ferreira, M. a. C., Badenes, R., Kurtz, P., Søndergaard, C. B., Colpaert, K., Petterson, L., Quintard, H., Cinotti, R., Bogossian, E. G., Righy, C., Silva, S., Roman-Pognuz, E., Vandewaeter, C., . . . Citerio, G. (2024). Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury. JAMA. https://doi.org/10.1001/jama.2024.20424 and  Turgeon, A. F., Fergusson, D. A., Clayton, L., Patton, M., Neveu, X., Walsh, T. S., Docherty, A., Malbouisson, L. M., Pili-Floury, S., English, S. W., Zarychanski, R., Moore, L., Bonaventure, P. L., Laroche, V., Verret, M., Scales, D. C., Adhikari, N. K. J., Greenbaum, J., Kramer, A., . . . Lauzier, F. (2024). Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. New England Journal of Medicine, 391(8), 722–735. https://doi.org/10.1056/nejmoa2404360

Dr. Benjamin Friedman will be presenting: Ashar, Y. K., Sun, M., Knight, K., Flood, T. F., Anderson, Z., Kaptchuk, T. J., & Wager, T. D. (2024). Open-Label Placebo Injection for Chronic Back Pain With Functional Neuroimaging. JAMA Network Open, 7(9), e2432427. https://doi.org/10.1001/jamanetworkopen.2024.32427

Dr. Kevin Gibbs will be presenting: Gibbs, K. W., Semler, M. W., Driver, B. E., Seitz, K. P., Stempek, S. B., Taylor, C., Resnick-Ault, D., White, H. D., Gandotra, S., Doerschug, K. C., Mohamed, A., Prekker, M. E., Khan, A., Gaillard, J. P., Andrea, L., Aggarwal, N. R., Brainard, J. C., Barnett, L. H., Halliday, S. J., . . . Casey, J. D. (2024). Noninvasive Ventilation for Preoxygenation during Emergency Intubation. New England Journal of Medicine, 390(23), 2165–2177. https://doi.org/10.1056/nejmoa2313680

Dr. Shannon Stephens will be presenting: Stephens, S. W., Carroll-Ledbetter, C., Duckert, S., Coffman, T., Nelson, M., Brown, K. N., Rodgers, J., Griffin, R. L., Suen, A., Casey, J., Sloan, S. R., Goldstein, B., McClintock, A. J., Goldkind, S. F., Gelinas, L., Higley, A. E., Joseph, B. A., Holcomb, J. B., Jansen, J. O., . . . Zreik, K. (2024). Interactive Media-Based Approach for an Exception From Informed Consent Trial Involving Patients With Trauma. JAMA Surgery. https://doi.org/10.1001/jamasurg.2024.2147

Dr. Lauren Mamer will be presenting: Li, G., Lin, Y., Yang, J., Anderson, C. S., Chen, C., Liu, F., Billot, L., Li, Q., Chen, X., Liu, X., Ren, X., Zhang, C., Xu, P., Wu, L., Wang, F., Qiu, D., Jiang, M., Peng, Y., Li, C., . . . Song, L. (2024). Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke. New England Journal of Medicine/˜the œNew England Journal of Medicine. https://doi.org/10.1056/nejmoa2314741

Dr. Sarah Perman will be presenting: Ashana, D. C., Welsh, W., Preiss, D., Sperling, J., You, H., Tu, K., Carson, S. S., Hough, C., White, D. B., Kerlin, M., Docherty, S., Johnson, K. S., & Cox, C. E. (2024). Racial Differences in Shared Decision-Making About Critical Illness. JAMA Internal Medicine, 184(4), 424. https://doi.org/10.1001/jamainternmed.2023.8433

Dr. Elizabeth Munroe will be presenting: Buell, K. G., Spicer, A. B., Casey, J. D., Seitz, K. P., Qian, E. T., Graham Linck, E. J., Self, W. H., Rice, T. W., Sinha, P., Young, P. J., Semler, M. W., & Churpek, M. M. (2024, April 9). Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults. JAMA, 331(14), 1195. https://doi.org/10.1001/jama.2024.2933

Dr. Renee Martin and Ms. Corinne Mcgill will be presenting:

Gallo, P., & Roychoudhury, S. (2023, February 3). Challenges in Implementing Futility Schemes, with Reference to Aducanumab. Therapeutic Innovation & Regulatory Science, 57(3), 515–520. https://doi.org/10.1007/s43441-023-00499-0

Ellenberg, S. S., & Shaw, P. A. (2022, June 28). Early Termination of Clinical Trials for Futility — Considerations for a Data and Safety Monitoring Board. NEJM Evidence, 1(7). https://doi.org/10.1056/evidctw2100020

This month we will be discussing two articles: 

Dr. Ramon Diaz-Arrastia will be presenting: Payen, J. F., Launey, Y., Chabanne, R., Gay, S., Francony, G., Gergele, L., Vega, E., Montcriol, A., Couret, D., Cottenceau, V., Pili-Floury, S., Gakuba, C., Hammad, E., Audibert, G., Pottecher, J., Dahyot-Fizelier, C., Abdennour, L., Gauss, T., Richard, M., . . . Mallaret, M. (2023, November). Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label, randomised controlled superiority trial. The Lancet Neurology, 22(11), 1005–1014. https://doi.org/10.1016/s1474-4422(23)00290-9

Dr. Jason McMullan will be presenting: Le Cornec, C., Le Pottier, M., Broch, H., Marguinaud Tixier, A., Rousseau, E., Laribi, S., Janière, C., Brenckmann, V., Guillerm, A., Deciron, F., Kabbaj, A., Jenvrin, J., Péré, M., & Montassier, E. (2024, January 29). Ketamine Compared With Morphine for Out-of-Hospital Analgesia for Patients With Traumatic Pain. JAMA Network Open, 7(1), e2352844. https://doi.org/10.1001/jamanetworkopen.2023.52844

Drs. Regina Royan and Brian Stamm will be presenting: Stamm, B., Royan, R., Giurcanu, M., Messe, S. R., Jauch, E. C., & Prabhakaran, S. (2023, August 15). Door-in-Door-out Times for Interhospital Transfer of Patients With Stroke. JAMA, 330(7), 636. https://doi.org/10.1001/jama.2023.12739

Dr. Anna Condella will be presenting: Sangal, R. B., Su, H., Khidir, H., Parwani, V., Liebhardt, B., Pinker, E. J., Meng, L., Venkatesh, A. K., & Ulrich, A. (2023, July 28). Sociodemographic Disparities in Queue Jumping for Emergency Department Care. JAMA Network Open, 6(7), e2326338. https://doi.org/10.1001/jamanetworkopen.2023.26338

Drs. David Vinson and Samuel Rouleau will be presenting: Rouleau, S. G., Balasubramanian, M. J., Huang, J., Antognini, T., Reed, M., & Vinson, D. R. (2023, August 2). Prevalence of and Eligibility for Surveillance Without Anticoagulation Among Adults With Lower-Risk Acute Subsegmental Pulmonary Embolism. JAMA Network Open; American Medical Association. https://doi.org/10.1001/jamanetworkopen.2023.26898

Dr. Connor O’Hare will be presenting: O’Hare, C., Grace, K. A., Schaeffer, W. J., Hyder, S. N., Stover, M. D., Liles, A., Khaja, M. S., Cranford, J. A., Kocher, K. E., Barnes, G. D., & Greineder, C. F. (2023, May 31). Adverse Clinical Outcomes Among Patients With Acute Low-risk Pulmonary Embolism and Concerning Computed Tomography Imaging Findings. JAMA Network Open; American Medical Association. https://doi.org/10.1001/jamanetworkopen.2023.11455

Dr. Sachin Agarwal, MD, MPH,  will be presenting Lilja, G., Ullén, S., Dankiewicz, J., Friberg, H., Levin, H., Nordström, E., Heimburg, K., Jakobsen, J. C., Ahlqvist, M., Bass, F., Bělohlávek, J., Olsen, R. B., Cariou, A., Eastwood, G. M., Fanebust, H. R., Grejs, A. M., Grimmer, L., Hammond, N., Hovdenes, J., . . . Cronberg, T. (2023, August 7). Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest. JAMA Neurology; American Medical Association. https://doi.org/10.1001/jamaneurol.2023.2536

Dr. Beth Slomine, PhD, will be presenting Hickson, M., Winters, M., Thomas, N. H., Gardner, M. M., Kirschen, M., Nadkarni, V., Berg, R. A., Slomine, B. S., Pinto, N., & Topjian, A. (2023, June 1). Long-term function, quality of life and healthcare utilization among survivors of pediatric out-of-hospital cardiac arrest. Resuscitation; Elsevier BV. https://doi.org/10.1016/j.resuscitation.2023.109768

Dr. Sarah Knack will be presenting: “The Effect of Ketamine versus Etomidate for Rapid Sequence Intubation on Maximum SOFA Score: A Randomized Clinical Trial”

Dr. Robert Silbergleit will be presenting: “Extracorporeal Life Support in Infarct-Related Cardiogenic Shock”

Dr. Daniel Nishijima will be presenting: Prehospital Tranexamic Acid for Severe Trauma. (2023, June 14). New England Journal of Medicine. https://doi.org/10.1056/nejmoa2215457

Dr. Rachel Thomas will be presenting: Hutchinson, P. J., Adams, H., Mohan, M., Devi, B. I., Uff, C., Hasan, S., Mee, H., Wilson, M. H., Gupta, D. K., Bulters, D., Zolnourian, A., McMahon, C. J., Stovell, M. G., Al-Tamimi, Y. Z., Tewari, M. K., Tripathi, M., Thomson, S., Viaroli, E., Belli, A., . . . Kolias, A. G. (2023, June 15). Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma. New England Journal of Medicine, 388(24), 2219–2229. https://doi.org/10.1056/nejmoa2214172

Dr. Lai Wei will present: and Redfors, B., Gregson, J., Crowley, A., McAndrew, T., Ben-Yehuda, O., Stone, G. W., & Pocock, S. J. (2020, September 9). The win ratio approach for composite endpoints: practical guidance based on previous experience. European Heart Journal, 41(46), 4391–4399. https://doi.org/10.1093/eurheartj/ehaa665

Dr Jonathan Beall will present: Beall, J., Elm, J., Chamberlain, J., Rosenthal, E., Kapur, J., & Durkalski-Mauldin, V. (2023, February 24). An Expected Score Approach to Ordinal Outcomes in a Bayesian, Response Adaptive, Randomized Trial. Statistics in Biopharmaceutical Research, 1–6. https://doi.org/10.1080/19466315.2023.2169344

Dr. Jarrod Mosier will present: Suverein, M. M., Delnoij, T. S., Lorusso, R., Brandon Bravo Bruinsma, G. J., Otterspoor, L., Elzo Kraemer, C. V., Vlaar, A. P., van der Heijden, J. J., Scholten, E., den Uil, C., Jansen, T., van den Bogaard, B., Kuijpers, M., Lam, K. Y., Montero Cabezas, J. M., Driessen, A. H., Rittersma, S. Z., Heijnen, B. G., Dos Reis Miranda, D., . . . van de Poll, M. C. (2023, January 26). Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest. New England Journal of Medicine, 388(4), 299–309. https://doi.org/10.1056/nejmoa2204511

Dr. Stephanie Demasi will present: Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. (2023, February 9). New England Journal of Medicine, 388(6), 499–510. https://doi.org/10.1056/nejmoa2212663

Dr. Nick Johnson will present: Kjaergaard, J., Møller, J. E., Schmidt, H., Grand, J., Mølstrøm, S., Borregaard, B., Venø, S., Sarkisian, L., Mamaev, D., Jensen, L. O., Nyholm, B., Høfsten, D. E., Josiassen, J., Thomsen, J. H., Thune, J. J., Obling, L. E. R., Lindholm, M. G., Frydland, M., Meyer, M. A. S., … Hassager, C. (2022). Blood-pressure targets in comatose survivors of cardiac arrest. New England Journal of Medicine, 387(16), 1456–1466. https://doi.org/10.1056/nejmoa2208687

Dr. Jeffrey Kline will present Sadeghipour, P., Jenab, Y., Moosavi, J., Hosseini, K., Mohebbi, B., Hosseinsabet, A., Chatterjee, S., Pouraliakbar, H., Shirani, S., Shishehbor, M. H., Alizadehasl, A., Farrashi, M., Rezvani, M. A., Rafiee, F., Jalali, A., Rashedi, S., Shafe, O., Giri, J., Monreal, M., . . . Bikdeli, B. (2022, December 1). Catheter-Directed Thrombolysis vs Anticoagulation in Patients With Acute Intermediate-High–risk Pulmonary Embolism. JAMA Cardiology, 7(12), 1189. https://doi.org/10.1001/jamacardio.2022.3591

Dr. Michael Harhay will present: Harhay, M. O., Blette, B. S., Granholm, A., Moler, F. W., Zampieri, F. G., Goligher, E. C., Gardner, M. M., Topjian, A. A., & Yehya, N. (2022). A bayesian interpretation of a pediatric cardiac arrest trial (THAPCA-OH). NEJM Evidence, 2(1). https://doi.org/10.1056/evidoa2200196

Drs. Guterman and Burke will present: Guterman, E. L., Sporer, K. A., Newman, T. B., Crowe, R. P., Lowenstein, D. H., Josephson, S. A., Betjemann, J. P., & Burke, J. F. (2022). Real-world midazolam use and outcomes with out-of-hospital treatment of status epilepticus in the United States. Annals of Emergency Medicine, 80(4), 319–328. https://doi.org/10.1016/j.annemergmed.2022.05.024 

Dr. Amy J. Zeidan will be presenting Vilcant, V., Ceron, C., Gagan, V., Zeltser, R., Makaryus, A.N. (2022). Inclusion of Under-Represented Racial and Ethnic Groups in Cardiovascular Clinical Trials. Heart, Lung and Circulation, 31: 1263-1268. https://doi.org/10.1016/j.hlc.2022.06.668

Blumenthal, D., James, C.V. (2022). A Data Infrastructure for Clinical Trial Diversity. N Engl J Med 2022; 386:2355-2356. DOI: 10.1056/NEJMp2201433

Dr. Cindy H. Hsu will be presenting Michos, E.D., Reddy, T.K., Gulati, M., Brewer, L.C., Bond, R.M., Velarde, G.P., Bailey, A.L., Echols, M.R., Nasser, S.A., Bays, H.E., Navar A.M., Ferdinand, K.C. (2022). Improving the enrollment of women and racially/ethnically diverse populations in cardiovascular clinical trials: An ASPC practice statement. American Journal of Preventive Cardiology, 8: 100250. https://doi.org/10.1016/j.ajpc.2021.100250

Woodcock, J., Araojo, R., D.Pharm., Thompson, T., D.Pharm., Puckrein, G.A. (2022). Integrating Research into Community Practice – Toward Increased Diversity in Clinical Trials. N Engl J Med 2021; 385:1351-1353. DOI: 10.1056/NEJMp2107331

Dr. Jason Allen will be presenting Haijun, W., Wright, D.W., Allen, J.W., Ding, V., Boothroyd, D., Glushakova, O.Y., Hayes, R., Jiang, B., Wintermark, M. (2022). Accuracy of head computed tomography scoring systems in predicting outcomes for patients with moderate to severe traumatic brain injury: A ProTECT III ancillary study. The Neuroradiology Journal, 0(0): 1-11. https://doi.org/10.1177/19714009221101313 

Dr. Frederick Korley will be presenting Korley, F., Jain, S., Sun, X., Puccio, A.M., Yue, J.K., Gardner, R.C., Wang, K., K.W., Okonkwo, D.O., Yuh, E.L., Mukherjee, P., Nelson, L.D., Taylor, S.R., Markowitz, A.J., Diaz-Arrastia, R., Manley, G.T., and the TRACK-TBI Study Investigators. (2022). Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study. Lancet Neurol, 21: 803-13. https://doi.org/10.1016/s1474-4422(22)00256-3 

Dr. Jan Claassen will be presenting Egbebike, J., Shen, Q., Doyle, K., Der-Nigoghossian, A., Panicker, L., Gonzales, I.J., Grobois, L., Carmona, J.C., Vrosgou, A., Kaur, A., Boehme, A., Velaquez, A., Rohaut, B., Roh, D., Agarwar, S., Park, S., Connolly, E.S., Claassen, J. (2022). Cognitive-motor dissociation and time to functional recovery in patients with acute brain injury in the USA: a prospective observational cohort study. Lancet Neurol, 21: 704-13. https://doi.org/10.1016/S1474-4422(22)00212-5

Dr. Mehul Patel will be presenting Chen, H.-S., Cui, Y., Li, X.-Q, et al. (2022). Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Fundtion in Patients with Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial. Jama, 328(7): 627-636. doi:10.1001/jama.2022.13123

Dr. David Sullivan will be presenting Sullivan, D. J., Gebo, K. A., Shoham, S., Bloch, E. M., Lau, B., Shenoy, A. G., Mosnaim, G. S., Gniadek, T. J., Fukuta, Y., Patel, B., Heath, S. L., Levine, A. C., Meisenberg, B. R., Spivak, E. S., Anjan, S., Huaman, M. A., Blair, J. E., Currier, J. S., Paxton, J. H., … Hanley, D. F. (2022). Early outpatient treatment for covid-19 with convalescent plasma. New England Journal of Medicine, 386(18), 1700–1711. https://doi.org/10.1056/nejmoa2119657

Dr. Robert Silbergleit will be presenting Turner, S. M. F., Sunshine, M. D., Chandran, V., Smuder, A. J., & Fuller, D. D. (2022). Hyperbaric oxygen therapy after mid-cervical spinal contusion injury. Journal of Neurotrauma, 39(9-10), 715–723. https://doi.org/10.1089/neu.2021.0412

Dr. Valerie Durkalski-Mauldin will be presenting: Hamming, K., & Taljaard, M. (2020). Reflection on modern methods: when is a stepped-wedge cluster randomized trial a good study design choice? International Journal of Epidemiology, 49 (3), 1043-1052. https://doi.org/10.1093/ije/dyaa077

Dr. Abigail Shoben will be presenting: Brown, S. P., & Shoben, A. B. (2020). Information growth for sequential monitoring of clinical trials with a stepped wedge cluster randomized design and unknown intracluster correlation. Clinical Trials, 17 (2), 176-183. https://doi.org/10.1177/1740774510369686

Drs. Emily Gilmore and Melvin Parasram will be presenting Ruijter, B. J., Keijzer, H. M., Tjepkema-Cloostermans, M. C., Blans, M. J., Beishuizen, A., Tromp, S. C., Scholten, E., Horn, J., van Rootselaar, A.-F., Admiraal, M. M., van den Bergh, W. M., Elting, J.-W. J., Foudraine, N. A., Kornips, F. H. M., van Kranen-Mastenbroek, V. H. J. M., Rouhl, R. P. W., Thomeer, E. C., Moudrous, W., Nijhuis, F. A. P., … Hofmeijer, J. (2022). Treating rhythmic and periodic EEG patterns in comatose survivors of cardiac arrest. New England Journal of Medicine, 386(8), 724–734. https://doi.org/10.1056/nejmoa2115998

Drs. Hyunah Yoon and Mila Ortigoza will be presenting Ortigoza, M. B., Yoon, H., Goldfeld, K. S., Troxel, A. B., Daily, J. P., Wu, Y., Li, Y., Wu, D., Cobb, G. F., Baptiste, G., O’Keeffe, M., Corpuz, M. O., Ostrosky-Zeichner, L., Amin, A., Zacharioudakis, I. M., Jayaweera, D. T., Wu, Y., Philley, J. V., Devine, M. S., … Hendrickson, J. E. (2022). Efficacy and safety of COVID-19 convalescent plasma in hospitalized patients. JAMA Internal Medicine, 182(2), 115. https://doi.org/10.1001/jamainternmed.2021.6850

Brian Driver, MD, will present: Driver, B.E., Semler, M.W., Self, W.H., et al.(2021). Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial. JAMA. 326(24). 2488–2497. doi:10.1001/jama.2021.22002

Jeffrey Kline, MD, will present: Le Gal, G., Kovacs, M. J., Bertoletti, L., Couturaud, F., Dennie, C., Hirsch, A. M., Huisman, M. V., Klok, F. A., Kraaijpoel, N., Mallick, R., Pecarskie, A., Pena, E., Phillips, P., Pichon, I., Ramsay, T., Righini, M., Rodger, M. A., Roy, P.-M., Sanchez, O., … Carrier, M. (2021). Risk for recurrent venous thromboembolism in patients with subsegmental pulmonary embolism managed without anticoagulation. Annals of Internal Medicine. https://doi.org/10.7326/m21-2981

Christopher Lindsell, MD, will present: Huie, J. R., Mondello, S., Lindsell, C. J., Antiga, L., Yuh, E. L., Zanier, E. R., Masson, S., Rosario, B. L., Ferguson, A. R., Adeoye, O., Badjatia, N., Boase, K., Bodien, Y., Bullock, M. R., Chesnut, R., Corrigan, J. D., Crawford, K., Diaz-Arrastia, R., Dikmen, S., … Zumbo, F. (2021). Biomarkers for traumatic brain injury: Data standards and statistical considerations. Journal of Neurotrauma, 38(18), 2514–2529. https://doi.org/10.1089/neu.2019.6762

Sharon Yeatts, PhD, will present: Retel Helmrich, I. R. A., Lingsma, H. F., Turgeon, A. F., Yamal, J.-M., & Steyerberg, E. W. (2021). Prognostic research in traumatic brain injury: Markers, modeling, and methodological principles. Journal of Neurotrauma, 38(18), 2502–2513. https://doi.org/10.1089/neu.2019.6708

Hayley Falk, MS, will present: Falk, H., Bechtold, K. T., Peters, M. E., Roy, D., Rao, V., Lavieri, M., Sair, H., Van Meter, T. E., & Korley, F. A Prognostic Model for Predicting One-Month Outcomes among Emergency Department Patients with Mild Traumatic Brain Injury and a Presenting Glasgow Coma Scale of Fifteen. Journal of Neurotrauma.Oct 2021.2714-2722.http://doi.org/10.1089/neu.2021.0137

Neethi ​Pinto, MD, & Alexis Topjian will present: Magee A., Deschamps R., Delzoppo C., Pan K. C., Butt W., Dagan M, Forrest A., & Namachivayam S. P. Temperature Management and Health-Related Quality of Life in Children 3 Years After Cardiac Arrest. Pediatric Critical Care Medicine. 2021 Aug 23. doi: 10.1097/PCC.0000000000002821. Online ahead of print.PMID: 34534164

Neal Dickert, MD will present: Piller, C. (2021). Failure to protect? Science, 373(6556), 729–733. https://doi.org/10.1126/science.373.6556.729

James Miner, MD will present:  Dickert, N. W., & Sugarman, J. (2018). Ethics and regulatory barriers to research in emergency settings. Annals of Emergency Medicine, 72(4), 386–388.  &  Klein, L. R., Driver, B. E., Miner, J. R., Martel, M. L., Hessel, M., Collins, J. D., Horton, G. B., Fagerstrom, E., Satpathy, R., & Cole, J. B. (2018). Intramuscular midazolam, olanzapine, ziprasidone, or haloperidol for treating acute agitation in the emergency department. Annals of Emergency Medicine, 72(4), 374–385. https://doi.org/10.1016/j.annemergmed.2018.04.027

Jordan Elm, PhD will present: Doernberg SB, Tran TTT, Tong SYC, Paul M, Yahav D, et al. Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection. Clin Infect Dis. 2019 May 2;68(10):1691-1698. 

Thevaa Chandereng, PhD will present: Wathen JK, Thall PF. A simulation study of outcome adaptive randomization in multi-arm clinical trials. Clin Trials. 2017;14(5):432-440.

Cindy Hsu, MD will present: Hsu CH, Meurer WJ, Domeier R, Fowler J, Whitmore SP, Bassin BS, et al.  Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest (EROCA): Results of a Randomized Feasibility Trial of Expedited Out-of-Hospital Transport. Ann Emerg Med. 2021 Feb 1;S0196-0644(20)31390-1.

Chris Richards, MD will present: Ebinger M, Siegerink B, Kunz A, Wendt M, Weber JE, Schwabauer E, et al. Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin. JAMA. 2021;325(5):454-466.

Daniel Nishijima, MD will present: Guyette FX, Brown JB, Zenati MS, Early-Young BJ, Adams PW, Eastridge BJ, et al. Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury, A Double-blind, Placebo-Controlled, Randomized Clinical Trial. JAMA Surg. 2021;156(1):11-20.

Editorial: Dumas RP and Martin MJ. Prehospital Tranexamic Acid, STAAMP of Approval or Return to Sender? JAMA Surg. 2021;156(1).

Jeffrey Kline, MD will present: Roy PM, Friou E, Germeau B, Douillet D, Kline JA, Righini M, et al. Derivation and Validation of a 4-Level Clinical Pretest Probability Score for Suspected Pulmonary Embolism to Safely Decrease Imaging Testing. JAMA Cardiol. 2021. Doi:10.1001/jamacardio.2021.0064.

Michael Puskarich will present: Libster R, Perez M, Wappner D, Coviello S, Bianchi A, Braem V, et al. Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. NEJM. 2021 January 6 at nejm.org.

TBD will present: Gottlieb RL, Nirula A, Chen P, Boscia J, Heller B, Morris J, et al. Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19, A Randomized Clinical Trial. JAMA. 2021 January 21 at jamanetwork.com.

Abhishek Sathe and Dr. Lisa Coles will present: Sathe A, Elm J, Cloyd J, Chamberlain J, Silbergleit R, Kapur J, et al. The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus. Epilepsia. 2020 Jun;61(6).

Abhishek Sathe and Dr. Lisa Coles will present: Sathe A, Underwood E, Coles L, Elm J, Silbergleit R, Chamberlain J, et al. Patterns of Benzodiazepine Underdosing in the Established Status Epilepticus Treatment Trial. Accepted to Epilepsia, January 2021 -not yet published.

Drs. Christopher Tignanelli and Lena Napolitano will present: Tignanelli CJ and Napolitano LM. The Fragility Index in Randomized Clinical Trials as a Means of Optimizing Patient Care. JAMA Surg. 2019;154(1):74-79.

Dr. Stephen Walter will present: Walter SD, Thabane L and Briel M. The Fragility of Trial Results Involves More Than Statistical Significance Alone. Journal of Clinical Epidemiology 2020;124:34-41.